Chlorhexidine is used in disinfectants (disinfection of the skin and hands), cosmetics (additive to creams, toothpaste, deodorants, and antiperspirants), and pharmaceutical products (preservative in eye drops, active substance in wound dressings and antiseptic mouthwashes). Cochrane review concluded that based on very low certainty evidence in those who are critically ill “it is not clear whether bathing with chlorhexidine reduces hospital‐acquired infections, mortality, or length of stay in the ICU, or whether the use of chlorhexidine results in more skin reactions.”[10]In endodontics, chlorhexidine is used for root canal irrigation and as an intracanal dressing,[11][12][13] but has been replaced by the use of sodium hypochlorite bleach in much of the developed world.


Chlorhexidine gluconate is a germicidal mouthwash that reduces bacteria in the mouth. There is strong evidence that it is more effective than povidone-iodine and is it proved to kill 99.9% of germs in 30 sec.


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